Drug Combinations With Aptivus to Avoid
Combining Aptivus and meperidine can cause a buildup of toxic meperidine metabolites. In general, these medications should not be taken together.
Aptivus can decrease the level of methadone in your blood, perhaps making it less effective. Your healthcare provider may need to increase your methadone dosage to prevent this interaction from occurring.
Aptivus capsules contain alcohol, which can cause severe reactions if combined with metronidazole.
Oral Diabetes Medications
Aptivus can interact with many diabetes medications that are taken by mouth. It is a good idea to monitor your blood sugar closely when starting or stopping Aptivus (or changing your Aptivus dosage).
Phosphodiesterase Type 5 Inhibitors (PDE5 Inhibitors)
Aptivus can increase the level of PDE5 inhibitors in your blood, increasing your risk of side effects. Your healthcare provider may recommend a lower-than-typical dosage for your PDE5 inhibitor while you are taking Aptivus.
PDE5 inhibitors are used to treat erectile dysfunction or pulmonary arterial hypertension. Specific dosing recommendations are available for combining Aptivus with a PDE5 inhibitor if the PDE5 inhibitor is used to treat erectile dysfunction. Also, specific dosing recommendations are available for combining Aptivus with tadalafil when tadalafil is used to treat pulmonary arterial hypertension.
However, at this time it is not recommended to combine Aptivus with sildenafil when sildenafil is used to treat pulmonary arterial hypertension, as a safe and effective dosing regimen has not yet been determined for this situation.
Pimozide and Aptivus should not be taken together, due to the risk of dangerous reactions.
Combining salmeterol with Aptivus may increase the risk of serious side effects of salmeterol, especially heart problems. Check with your healthcare provider before combining such medications. In general, these medications should not be combined.
Some Statin Medications