Aptivus Drug Interactions

When certain medications are taken with Aptivus, drug interactions may occur. These interactions could increase your risk for side effects and decrease the effectiveness of the medicines. Some of the medications that can lead to negative Aptivus drug interactions include calcium channel blockers, oral diabetes medicines, hormonal contraceptives, and antidepressants. To prevent interactions, your healthcare provider may adjust your dosages.

 

Aptivus Drug Interactions: An Overview

Aptivus® (tipranavir) can potentially interact with several other medicines. Some of the medicines that may lead to drug interactions with Aptivus include:
 
 
 
  • Certain antibiotics and antifungal medications, such as:
 
    • Clarithromycin (Biaxin®)
    • Fluconazole (Diflucan®)
    • Ketoconazole (Nizoral®)
    • Itraconazole (Sporanox®)
    • Rifabutin (Mycobutin®)
    • Rifampin (Rifadin®)
    • Voriconazole (Vfend®)
 
  • Certain benzodiazepines, such as:
 
 
  • Certain other protease inhibitors, such as:
 
 
 
 
  • Ergot medications, such as:
 
    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergonovine
    • Ergotamine (Bellamine S®, Cafergot®, Ergomar®)
    • Methylergonovine (Methergine®)
    • Pergolide (Permax®)
 
 
    • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
    • Sirolimus (Rapamune®)
    • Tacrolimus (Prograf®)

 

  • Medications with anticoagulant or antiplatelet activity, such as:
     
    • Aspirin (Bayer® and others)
    • Clopidogrel (Plavix®)
    • Heparin or heparin-like products, such as:
 
      • Dalteparin (Fragmin®)
      • Enoxaparin (Lovenox®)
      • Tinzaparin (Innohep®)
 
    • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
 
 
    • Warfarin (Coumadin®, Jantoven®)
 
 
 
(Aptivus Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;