Taking Atripla With Other Medicines
In general, Atripla should not be taken with medications that contain lamivudine, since emtricitabine (one of the components of Atripla) and lamivudine are similar medications.
Efavirenz (one of the components of Atripla) may decrease the level of Maraviroc in your blood, perhaps making it less effective. If you take these medications together, you may need a higher Maraviroc dosage.
Atripla can decrease the level of methadone in your blood, perhaps making it less effective. Your healthcare provider may need to increase your methadone dosage to prevent this interaction from occurring.
NSAIDs may interfere with the kidneys' ability to remove Atripla from the blood. In addition, combining Atripla with high doses of an NSAID or with multiple NSAIDs may increase the risk of kidney failure. It's best to check with your healthcare provider before combining Atripla with any NSAID, including nonprescription ones.
Pimozide and Atripla should not be taken together, due to the risk of serious or life-threatening reactions, such as an irregular heart rhythm (arrhythmia).
Combining Atripla with a protease inhibitor can either increase or decrease the level of Atripla and the protease inhibitor in your blood. Your healthcare provider may need to adjust the dose of Atripla and your protease inhibitor to prevent this.
Combining raltegravir with Atripla may decrease the levels of raltegravir in the blood, perhaps making it less effective. It is not yet known how best to handle this interaction. Check with your healthcare provider before combining these medications.