Combivir Drug Interactions

If certain medications are combined with Combivir, drug interactions can occur. Depending on the medication, these interactions can decrease the medications' effectiveness or increase your risk of potentially serious side effects. Medications that can cause Combivir drug interactions include interferon medications, fluconazole, methadone, and probenecid. If drug interactions are a concern, your healthcare provider may decide to monitor you more closely.

 

Combivir Drug Interactions: An Introduction

Combivir® (lamivudine/zidovudine) can potentially interact with several other medicines. Some of these medicines that may lead to Combivir drug interactions include:
 
  • Atovaquone (Mepron®)
  • Doxorubicin (Adriamycin®, Doxil®, Evacet™)
  • Fluconazole (Diflucan®)
  • Ganciclovir (Cytovene®)
  • Interferon medications, such as:
     
    • Interferon alfa-2a (Roferon®-A)
    • Interferon alfa-2b (Intron® A)
    • Interferon alfa-2b and ribavirin (Rebetron®)
    • Interferon alfa-n3 (Alferon® N)
    • Interferon alfacon-1 (Infergen®)
    • Interferon beta-1a (Avonex®, Rebif®)
    • Interferon beta-1b (Betaseron®)
    • Interferon gamma-1b (Actimmune®)
    • Peginterferon alfa-2a (Pegasys®)
    • Peginterferon alfa-2b (PEG-Intron®)
 
(Combivir Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;