Invirase Drug Interactions

When arrhythmia medications, calcium channel blockers, and certain antibiotics are taken with Invirase, drug interactions may occur. Some of these interactions can alter the amount of the medications in your blood, possibly increasing your risk of side effects or decreasing the effectiveness of the medications. If Invirase drug interactions are a concern, your healthcare provider may monitor you more closely and adjust your dosages as necessary.

 

Invirase Drug Interactions: An Overview

Invirase® (saquinavir mesylate) can potentially interact with several other medicines. Some of the medicines that may lead to Invirase drug interactions include:
 
 
 
  • Certain antibiotics and antifungal medications, such as:
 
    • Clarithromycin (Biaxin®)
    • Ketoconazole (Nizoral®)
    • Itraconazole (Sporanox®)
    • Rifabutin (Mycobutin®)
    • Rifampin (Rifadin®)
 
  • Certain benzodiazepines, such as:
 
 
  • Certain other protease inhibitors, such as:
 
 
 
 
  • Ergot medications, such as:
 
    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergonovine
    • Ergotamine (Bellamine S®, Cafergot®, Ergomar®)
    • Methylergonovine (Methergine®)
    • Pergolide (Permax®)
 
 
    • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
    • Sirolimus (Rapamune®)
    • Tacrolimus (Prograf®)
 
  • Methadone (Dolophine®, Methadose®)
  • Nevirapine (Viramune®)
  • Pimozide (Orap®)
  • Proton pump inhibitors (PPIs), such as:
 
 
 
 
 
 
 
 
  • Warfarin (Coumadin®, Jantoven®).
     
(Invirase Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;