Is Invirase Dangerous?

Specific Invirase Warnings and Precautions

Warnings and precautions to be aware of prior to taking Invirase include the following:
 
  • Invirase must be taken with ritonavir (Norvir®), another HIV medication. Taking Invirase without ritonavir will decrease the level of Invirase in your blood, making it less effective.

 

  • Invirase can cause potentially serious changes in the heart rhythm. People at a high risk for serious problems due to these heart rhythm changes include people with heart disease, low magnesium levels, low potassium levels, or liver disease. If your healthcare provider thinks you might be at a high risk for such problems, your heart rhythm may need to be monitored periodically.
     
  • There are some medications that should never be taken with Invirase, due to the risk of a life-threatening irregular heart rhythm (arrhythmia) or other serious problems (see Invirase Drug Interactions).
      
  • The liver helps to remove Invirase from the blood. Invirase can make liver disease worse. Make sure to tell your healthcare provider if you already have liver disease or liver damage prior to taking Invirase.
     
  • Invirase can cause high blood sugar (hyperglycemia). This can cause problems for people who have diabetes, or it can even cause diabetes in individuals who are at risk for this condition.
     
  • It is not known if it is safe for people with severe kidney disease to take Invirase.
     
  • Invirase can increase triglyceride and cholesterol levels. Your healthcare provider should monitor your cholesterol and triglyceride levels while you are taking the drug.
     
  • There have been reports of bleeding possibly due to protease inhibitors (such as Invirase) in people with hemophilia. Be sure your healthcare provider knows if you have this condition.
     
  • Invirase can change the distribution of fat on your body. You may gain fat in areas that are not typical for you, such as in the abdomen or at the back of the neck (a "buffalo hump"), and you may lose weight in other areas.
     
  • Invirase is not a cure for HIV or AIDS. If you have HIV or AIDS, you should always use safer sex practices, whether or not you are taking medications.
     
  • As with all HIV medications, it is important that you take Invirase exactly as prescribed. Missing doses may increase the chance of the virus becoming resistant to HIV medications. 

 

  • Invirase is considered a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are not known (see Invirase and Pregnancy).
     
  • It is not known if Invirase passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Invirase and Breastfeeding). It is important to understand that the HIV virus can be transmitted through breast milk and that breastfeeding is usually not recommended in women with HIV or AIDS.
     

Invirase Drug Information

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