Isentress Drug Interactions

When Isentress is taken with drugs such as atazanavir, phenobarbital, and phenytoin, interactions could occur. Interactions such as these may alter the amounts of medications in the blood, possibly making them less effective. However, many of these drug interactions with Isentress have not been adequately studied, so you should talk to your healthcare provider before taking any medications with Isentress.

Isentress for HIV/AIDS

Drug Interactions With Isentress: An Overview

Isentress^™ (raltegravir) can potentially interact with several other medicines. Some of the medicines that may lead to Isentress drug interactions include:

Atazanavir (Reyataz^®)
Efavirenz (Sustiva^®)
Etravirine (Intelence^™)
H2 blockers, such as:
- Cimetidine (Tagamet^®)
- Famotidine (Pepcid^®)
- Nizatidine (Axid^®)
- Ranitidine (Zantac^®)

Phenobarbital (Luminal^®)
Phenytoin (Dilantin^®)
Proton pump inhibitors (PPIs), including:
- Dexlansoprazole (Kapidex^™)
- Esomeprazole (Nexium^®)
- Lansoprazole (Prevacid^®)
- Omeprazole (Prilosec^®)
- Pantoprazole (Protonix^®)
- Rabeprazole (AcipHex^®)

Rifampin (Rifadin^®)
Tipranavir (Aptivus^®) combined with ritonavir (Norvir^®).

Isentress Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Isentress is combined with any of the drugs listed above.

(Isentress Drug Interactions Continued: Page 2)