More Medications That Interfere With Kaletra

Metronidazole
Kaletra oral solution (but not tablets) contains alcohol, which may cause problems when combined with metronidazole.
 
Nevirapine
Nevirapine can lower the level of Kaletra in your blood, perhaps making it less effective. Your healthcare provider may need to increase your Kaletra dosage to prevent this. When used in combination with nevirapine, once-daily dosing with Kaletra is not recommended (it should be taken twice a day instead).
 
Other Protease Inhibitors
Taking Kaletra with another protease inhibitor may increase or decrease the level of both medications in your blood. Check with your healthcare provider before taking Kaletra with another protease inhibitor.
 
In addition, combining atazanavir with Kaletra may increase the risk of a certain irregular heart rhythm known as heart block. This may be quite dangerous. If you take these medications together, your healthcare provider may want to monitor your heart to check for this problem.
 
Phosphodiesterase Type 5 Inhibitors (PDE5 Inhibitors)
Kaletra can increase the level of PDE5 inhibitors in your blood, increasing your risk of side effects. Your healthcare provider may recommend a lower-than-typical dosage for your PDE5 inhibitor while you are taking Kaletra.
 
PDE5 inhibitors are used to treat erectile dysfunction or pulmonary arterial hypertension. Specific dosing recommendations are available for combining Kaletra with a PDE5 inhibitor if the PDE5 inhibitor is used to treat erectile dysfunction. Also, specific dosing recommendations are available for combining Kaletra with tadalafil when tadalafil is used to treat pulmonary arterial hypertension.
 
However, at this time it is not recommended to combine Kaletra with sildenafil when sildenafil is used to treat pulmonary arterial hypertension, as a safe and effective dosing regimen has not yet been determined for this situation.
  
Pimozide
Pimozide and Kaletra should not be taken together, due to the risk of dangerous reactions.
 
Rifampin
Kaletra should never be combined with rifampin. Doing so may make Kaletra (and other similar HIV medications) permanently less effective.
 
Salmeterol
Combining salmeterol with Kaletra may increase the risk of serious side effects of salmeterol (especially heart problems). Check with your healthcare provider before combining these medications.
  
Seizure Medications
Some seizure medications can decrease the level of Kaletra in your blood, perhaps making it less effective. Check with your healthcare provider before taking Kaletra with a seizure medication.
Additionally, Kaletra may decrease the level of phenytoin in your blood. If you take Kaletra with phenytoin, your healthcare provider should monitor the level of phenytoin in your blood and adjust your phenytoin dosage as necessary.
 
Kaletra may decrease the levels of lamotrigine or valproate (divalproex, valproic acid) in your blood, making these medications less effective. Your healthcare provider may need to increase the dose of your anticonvulsant medication, and blood levels of lamotrigine or valproate may need to be monitored while taking Kaletra.

Kaletra Medication Information

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