Kaletra Drug Interactions

When certain medications (including delavirdine, efavirenz, and fluticasone) are taken with Kaletra, drug interactions could occur. These interactions can reduce the effectiveness of the medicines or increase your risk for developing serious side effects. Other medications that may cause Kaletra drug interactions include hormonal contraceptives, methadone, statins, and other protease inhibitors. To prevent interactions, your healthcare provider may adjust your dosages.

Kaletra Drug Interactions: An Overview

Kaletra® (lopinavir and ritonavir) can potentially interact with several other medicines. Some of the medicines that may lead to Kaletra drug interactions include:
 
 

 

  • Certain antibiotics and antifungal medications, such as:
 
    • Clarithromycin (Biaxin®)
    • Ketoconazole (Nizoral®)
    • Itraconazole (Sporanox®)
    • Rifabutin (Mycobutin®)
    • Rifampin (Rifadin®)
    • Voriconazole (Vfend®)
 
  • Certain benzodiazepines, such as:
 

 

 
 
  • Ergot medications, such as:
 
    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergonovine
    • Ergotamine (Bellamine S®, Cafergot®, Ergomar®)
    • Methylergonovine (Methergine®)
    • Pergolide (Permax®)
 
  • Fluticasone (Flonase®, Flovent®, Veramyst®) or combination medications that contain fluticasone (Advair®)
  • Immune-suppressing medications, such as:
 
    • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
    • Sirolimus (Rapamune®)
    • Tacrolimus (Prograf®)
 
 
 
  • Pimozide (Orap®)
  • Medications that cause a certain irregular heart rhythm known as QT prolongation (see QT-Prolonging Medications) 
  • Rifampin (Rifadin®)
  • Seizure medications
  • Some statin medications, such as:
 
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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