Side Effects of Liposomal Doxorubicin

Liposomal doxorubicin, like many chemotherapy drugs, has the potential to cause serious reactions. Commonly reported side effects of liposomal doxorubicin include vomiting, mouth sores, and hair loss. If you are being treated with this medication, seek immediate medical care if you develop stinging during the IV infusion, blood in the stool, or difficulty breathing.

An Introduction to Liposomal Doxorubicin Side Effects

As with any medicine, side effects are possible with liposomal doxorubicin (Doxil®). As is common with chemotherapy medications, many of the drug's side effects are quite serious.
(This article covers many, but not all, of the possible side effects with this drug. Your healthcare provider can discuss a more complete list of liposomal doxorubicin side effects with you.)

Side Effects to Report

Some side effects with liposomal doxorubicin are quite serious and should be reported to your healthcare provider. These include but are not limited to:
  • Signs of congestive heart failure, including difficulty breathing and swelling or water retention
  • An irregular heart rhythm (arrhythmia)
  • Severe nausea, vomiting, and diarrhea
  • Blood in the stool
  • Burning or stinging during the IV infusion (this may be a sign that the medication is leaking from your vein, which is dangerous)
  • Signs of an infection, such as fever or chills (see Chemotherapy and Infections)
  • Severe mouth sores (see Mouth and Gum Problems During Chemotherapy)
  • Signs of an allergic reaction or infusion reaction, such as:
    • Unexplained rash, hives, or itching
    • Unexplained swelling
    • Flushing
    • Shortness of breath
    • Facial swelling
    • Headache
    • Chills
    • Back pain
    • Tightness of the chest or throat
    • Low blood pressure.
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Liposomal Doxorubicin Information

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