More Info on Liposomal Doxorubicin Indications

How Does This Medication Work?

Liposomal doxorubicin is part of a group of medications called anthracyclines. Anthracyclines kill cells (including cancer cells and normal cells) by working in several ways. Liposomal doxorubicin binds to DNA in cells, changing the shape of the DNA and causing other problems with the DNA. The medicine can damage the membranes (outer coating) of cells and may damage other parts of cells as well.
 
While liposomal doxorubicin can kill both healthy and cancerous cells, it has a greater effect on cells that are multiplying rapidly. In general, cancer cells multiply more rapidly than healthy cells, and are therefore more affected by liposomal doxorubicin.
 
Liposomal doxorubicin is a pegylated liposomal formulation of doxorubicin. This means that the drug molecules are trapped within liposomes (tiny fatty bubbles). This changes how the medication is distributed throughout the body and increases the time it lasts in the body. It is thought that liposomal doxorubicin is less toxic to heart tissues but more toxic to skin tissues, compared to nonliposomal doxorubicin.
 

Can Children Use Liposomal Doxorubicin?

Liposomal doxorubicin is approved only for people age 18 and older, as it has not been adequately studied in children. Talk with your child's healthcare provider about the benefits and risks of using liposomal doxorubicin in children.
 

Can It Be Used Off-Label?

On occasion, your healthcare provider may recommend this drug for something other than the conditions discussed in this article. Using liposomal doxorubicin to treat any type of cancer other than ovarian cancer, AIDS-related Kaposi's sarcoma, or multiple myeloma would be considered an off-label use.
 
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Liposomal Doxorubicin Information

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