AIDS Home > Agenerase Side Effects

Nausea, diarrhea, and vomiting are among the most commonly reported Agenerase side effects in adults. However, it is difficult to tell if these side effects are due to Agenerase or other factors, because no clinical studies have been done on the medication alone. Contact your healthcare provider immediately if you experience more serious side effects of Agenerase, such as depression or signs of an allergic reaction.

Agenerase Side Effects: An Introduction

As with any medicine, side effects are possible with Agenerase® (amprenavir). However, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Agenerase. Your healthcare provider can discuss a more complete list of Agenerase side effects with you.)
Agenerase is no longer available in the United States. The manufacturer stopped making it due to low demand, since it has been largely replaced by fosamprenavir (Lexiva®), a similar medication.

Common Agenerase Side Effects

Clinical studies have not evaluated Agenerase alone for the treatment of HIV, because the drug is meant to be used along with other HIV medications. In fact, the available information on potential side effects involves studies that used Agenerase plus one or two other HIV medications. Therefore, it is difficult to know if these side effects are due to Agenerase or the other HIV medications.
In these studies, the most common side effects of Agenerase (plus one or two other HIV medications) in adults included:
  • Nausea -- in up to 74 percent of people
  • Diarrhea or loose stools -- up to 60 percent
  • Vomiting -- up to 34 percent
  • Unusual sensations (like numbness, burning, or tingling) in or around the mouth -- up to 31 percent
  • Headaches -- up to 16 percent
  • Unusual sensations (like numbness, burning, or tingling) in the hands or feet -- up to 14 percent
  • Fatigue -- up to 14 percent
  • High triglycerides -- up to 13 percent
  • Changes in taste -- up to 10 percent.
In children, vomiting was a common Agenerase side effect, occurring in up to 56 percent of children.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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