Agenerase is approved for use in combination with other medications to treat HIV and AIDS. It works by inhibiting the multiplication process of the HIV virus. The medication comes in a capsule or oral solution (liquid) form and is typically taken two or three times a day. Possible side effects of Agenerase include nausea, vomiting, and a rash.
What Is Agenerase?
Agenerase® (amprenavir) is a prescription medicine used to treat HIV and AIDS. It is only approved for use in combination with other HIV medications.
Agenerase is no longer available in the United States. The manufacturer stopped making it due to low demand, since it has been largely replaced by fosamprenavir (Lexiva®), a similar medication.
Who Makes Agenerase?
Agenerase is made by GlaxoSmithKline.
How Does Agenerase Work?
Agenerase belongs to a group of HIV medications known as protease inhibitors. These medicines work by blocking a process that the HIV virus needs in order to multiply.
HIV (human immunodeficiency virus) is the virus that causes AIDS. Like other viruses, it must use a person's own cells to reproduce. Once inside an infected cell, the HIV virus uses the cell to make DNA, which enables it to make new HIV viruses that can spread to other cells. The DNA is made in long strands that must be clipped into shorter, usable strands using enzymes called proteases.
Agenerase is a protease inhibitor, which means that it stops protease enzymes from clipping DNA into short strands. Because the long, unclipped DNA strands cannot be used to make new viruses, this can stop the spread of HIV to uninfected cells. Agenerase is not a cure for HIV or AIDS, however. Although the medication can help prevent the HIV virus from infecting healthy cells in the body, it cannot help the cells that have already been infected with the virus.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Agenerase Capsules [package insert]. Research Triangle Park, NC: GlaxoSmithKline;2005 May.
Agenerase Oral Solution [package insert]. Research Triangle Park, NC: GlaxoSmithKline;2005 May.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed February 7, 2014.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 7th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2005.
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