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Atripla is an HIV and AIDS medication that is available by prescription. It contains three drugs from three different classes of HIV medications, all of which work by preventing the HIV virus from multiplying and spreading to uninfected cells in the body. While most people tolerate Atripla tablets well, potential side effects include fatigue, dizziness, headaches, and diarrhea.

What Is Atripla?

Atripla™ (efavirenz, emtricitabine, and tenofovir disoproxil fumarate) is a prescription medication used as a treatment for HIV and AIDS. It is approved for use alone or in combination with other HIV medications. Atripla contains three different medications:
(Click Atripla Uses for more information, including possible off-label uses.)

Who Makes It?

Atripla is made jointly by Bristol-Myers Squibb and Gilead Sciences, Inc.

How Does Atripla Work?

Tenofovir (one of the components of Atripla) is currently the only medication in a class of HIV medications known as nucleotide reverse transcriptase inhibitors (NtRTIs). Emtricitabine belongs to a group of medications known as nucleoside reverse transcriptase inhibitors (NRTIs), and efavirenz belongs to a group of HIV medications known as non-nucleoside reverse transcriptase inhibitors (NNRTIs). Although these three medications come from different medication classes, they all work similarly. Atripla blocks a process that the HIV virus needs in order to multiply.
HIV (human immunodeficiency virus) is the virus that causes AIDS. Like other viruses, it must use a person's own cells to reproduce. However, HIV is a little different from many other viruses because it must first convert its genetic material from RNA to DNA. It is the DNA genes that allow HIV to multiply.
HIV converts its genetic material by using a special protein called the reverse transcriptase enzyme. To create DNA, this enzyme uses several different molecular building-blocks.
Atripla works by tricking reverse transcriptase into thinking it is one of these molecular building-blocks. However, it is just different enough that when used to create DNA, the medication actually stops the DNA from being made. Without DNA, HIV cannot multiply. Atripla is not a cure for HIV or AIDS, however. It can help stop HIV from infecting healthy cells in the body, but it does not help cells that have already been infected with the virus.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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