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Complera Drug Interactions Explained

The following sections explain in detail the potentially negative reactions that can occur when Complera is combined with any of the drugs listed above.
Antacids can decrease the absorption of Complera into the bloodstream, causing it to be less effective. Make sure to take antacid medications at least two hours before or four hours after your dose of Complera.
Certain Antibiotics or Antifungals
Combining Complera with certain antibiotics or antifungals may increase the level of Complera in your blood, and may even decrease the level of some antifungals in your blood. Check with your healthcare provider before taking Complera with any of these medications.
Certain Seizure Medications
Complera should never be combined with carbamazepine, oxcarbazepine, phenobarbital, or phenytoin, as these medications can significantly decrease the effectiveness of Complera.
Complera should never be combined with more than a single dose of dexamethasone, as it can significantly decrease the effectiveness of Complera. A single, one-time dose of dexamethasone is acceptable.
H2 Blockers
H2 blockers can decrease the absorption of Complera, making it less effective. If you absolutely must take an H2 blocker, make sure to take it at least 12 hours before or 4 hours after a dose of Complera. It is probably not possible to take H2 blockers twice a day while taking Complera.
Complera can decrease the level of methadone in your blood, perhaps making it less effective. Your healthcare provider may need to increase your methadone dosage.
NSAIDs may interfere with the kidneys' ability to remove Complera from the blood. In addition, combining Complera with high doses of an NSAID or with multiple NSAIDs may increase the risk of kidney failure. It's best to check with your healthcare provider before combining Complera with any NSAID, including nonprescription ones.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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