AIDS Home > Complera Drug Interactions

Proton Pump Inhibitors (PPIs)
Complera should never be combined with PPIs, as these medications can significantly decrease the effectiveness of Complera.
QT-Prolonging Medications
Several medications can cause a change in the heart rhythm known as QT prolongation, to varying degrees. If severe enough, this change can lead to a life-threatening arrhythmia known as torsades de pointes. Because Complera can cause QT prolongation, especially at higher-than-recommended dosages, it should be used cautiously in combination with other QT-prolonging drugs.
Other NNRTIs
Complera is an NNRTI and should not be combined with other NNRTIs.
Rifabutin, Rifampin, or Rifapentine
Complera should never be combined with rifabutin, rifampin, or rifapentine, as these medications can significantly decrease the effectiveness of Complera.
St. John's Wort
Because St. John's wort can significantly decrease the level of Complera in your blood, these medications should never be taken together.

Final Thoughts

It is possible that not all drug interactions with Complera were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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