AIDS Home > Complera Drug Interactions
Proton Pump Inhibitors (PPIs)
Complera should never be combined with PPIs, as these medications can significantly decrease the effectiveness of Complera.
Several medications can cause a change in the heart rhythm known as QT prolongation, to varying degrees. If severe enough, this change can lead to a life-threatening arrhythmia known as torsades de pointes. Because Complera can cause QT prolongation, especially at higher-than-recommended dosages, it should be used cautiously in combination with other QT-prolonging drugs.
Complera is an NNRTI and should not be combined with other NNRTIs.
Rifabutin, Rifampin, or Rifapentine
Complera should never be combined with rifabutin, rifampin, or rifapentine, as these medications can significantly decrease the effectiveness of Complera.
St. John's Wort
Because St. John's wort can significantly decrease the level of Complera in your blood, these medications should never be taken together.