AIDS Home > Crixivan Warnings and Precautions

Before starting HIV treatment with Crixivan, warnings and precautions for the drug should be discussed with your healthcare provider to help minimize risks. Prior to taking Crixivan, make sure to tell your healthcare provider if you have liver disease, diabetes, or hemophilia. It is important to know that Crixivan may cause kidney stones, changes in body fat distribution, hepatitis, and high blood sugar.

Crixivan: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Crixivan® (indinavir sulfate) if you have:
Also, let your healthcare provider know if you are:


  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also be sure to tell your healthcare provider about all other medicines you are taking, including prescription and prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Crixivan

Warnings and precautions to be aware of prior to taking Crixivan include the following:
  • Crixivan frequently causes kidney stones. In order to help prevent kidney stones, you should stay hydrated while taking Crixivan (drink at least six cups of fluids a day).
  • Crixivan can destroy red blood cells (this is known as hemolytic anemia). If you develop this problem while taking Crixivan, your healthcare provider should recommend that you stop taking Crixivan.
  • Crixivan can cause hepatitis (inflammation of the liver). Make sure to tell your healthcare provider if you already have liver disease or liver damage, as you may need a lower Crixivan dosage.
  • Crixivan can cause high blood sugar (hyperglycemia). This can cause problems for people with diabetes or can even cause diabetes in individuals who are predisposed to the condition.
  • There have been reports of bleeding possibly due to protease inhibitors (such as Crixivan) in people with hemophilia. Be sure your healthcare provider knows if you have hemophilia.
  • It is not known whether Crixivan can safely be taken by people with kidney disease.
  • Crixivan can change the distribution of fat on your body. You may gain fat in areas that are not typical for you, such as in the abdomen or at the back of the neck (a "buffalo hump"), and may lose weight in other areas.
  • Crixivan is not a cure for HIV or AIDS. If you have HIV or AIDS, you should always use safer sex practices, regardless of whether you are taking medications.
  • As will all HIV medications, it is important that you take Crixivan exactly as prescribed. Missing doses may increase the chance of the virus becoming resistant to HIV medications.
  • Crixivan can interact with a number of different medications (see Crixivan Drug Interactions for more information).
  • Crixivan is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Crixivan and Pregnancy).
  • It is not known if Crixivan passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Crixivan and Breastfeeding). It is important to understand that the HIV virus can be transmitted through breast milk and that breastfeeding is usually not recommended in women with HIV or AIDS.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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