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The liver plays a role in the breakdown of several different medications. If these drugs are combined with Egrifta, interactions may occur that could interfere with the drugs' effectiveness or increase a person's risk of side effects. Your healthcare provider may adjust your dosages or monitor you more closely, depending on your particular situation.
Does Egrifta Interact With Other Drugs?It is not yet clear how (or even if) Egrifta™ (tesamorelin acetate) may react with other drugs. However, the medication may, at least theoretically, affect how the body breaks down (metabolizes) certain other drugs.
Many medications are metabolized by enzymes in the liver. One study showed that Egrifta did not have a significant effect on CYP 3A4 enzymes (CYP 3A4 is one of the enzymes that metabolizes several medications). However, there are several different types of liver enzymes, and it is unknown if Egrifta might affect any of those.
Egrifta works by causing the body to produce more growth hormone. Previous research suggests that changes in growth hormone may have an influence on liver enzymes, perhaps changing the way the liver metabolizes medications. Therefore, it is wise for your healthcare provider to carefully monitor your medications in terms of their effectiveness and side effects when you start or stop taking Egrifta.
Increased growth hormone production in the body can decrease cortisol levels. People being treated for adrenal insufficiency may need increased glucocorticoid doses after beginning Egrifta treatment. This interaction is most likely to occur in people taking cortisone or prednisone.
It is possible that not all drug interactions with Egrifta were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.