AIDS Home > Intelence

Intelence is a prescription drug approved for treating HIV and AIDS. It should be used in combination with other medications as part of an HIV "cocktail" and should only be prescribed to people who are resistant to other HIV medications. The medication comes in tablet form and is typically taken twice a day after meals. Potential side effects include nausea and a rash.

What Is Intelence?

Intelence® (etravirine) is a prescription medicine used as a treatment for HIV and AIDS. It is approved for use only in combination with other HIV medications and only in people who have developed resistance to other HIV medications. Intelence is approved for use in adults and children as young as six years of age.
 
(Click Intelence Uses for more information, including possible off-label uses.)
 

Who Makes It?

Intelence is made by Janssen-Cilag S.p.A. for Janssen Therapeutics.
 

How Does Intelence Work?

Intelence belongs to a group of HIV medications known as non-nucleoside reverse transcriptase inhibitors (NNRTIs). These medicines work by blocking a process that the HIV virus needs in order to multiply.
 
HIV (human immunodeficiency virus) is the virus that causes AIDS. Like other viruses, HIV must use a person's own cells to reproduce. However, HIV is a little different from other viruses because it must first convert its genetic material from RNA to DNA. It is the DNA genes that allow HIV to multiply.
 
HIV converts its genetic material by using a special protein called the reverse transcriptase enzyme. To create DNA, this enzyme uses several different molecular building blocks. Intelence works by attaching to the reverse transcriptase enzyme, stopping it from making DNA. Without DNA, HIV cannot multiply. This causes a decrease in "viral load" (the amount of HIV in the blood), which can decrease the risk of progression to AIDS and death.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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