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Diarrhea, nausea, and headaches are among the most commonly reported Isentress side effects. Those that are less common (occurring in 1 to 2 percent of people) include vomiting, weakness, and fatigue. Although most side effects of Isentress are minor and easily treated, some may require medical attention. Notify your healthcare provider right away if you develop signs of kidney damage, anemia, or allergic reactions.

Isentress Side Effects: An Introduction

As with any medicine, side effects are possible with Isentress® (raltegravir). However, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Isentress. Your healthcare provider can discuss a more complete list of Isentress side effects with you.)

Common Isentress Side Effects

Clinical studies have not evaluated Isentress alone for the treatment of HIV because it is only approved for use with other HIV medications. In fact, the information that is available on the potential side effects involves studies that used Isentress plus other HIV medications. Therefore, it is difficult to know whether these side effects are due to Isentress or the other HIV medications. In these studies, the most common side effects of Isentress (plus other HIV medications) included:
  • Diarrhea -- in up to 16.6 percent of people
  • Nausea -- up to 9.9 percent
  • Headaches -- up to 9.7 percent
  • Fever -- up to 4.9 percent.
Other common side effects (occurring in 1 to 2 percent of people) included:
  • Abdominal pain (stomach pain)
  • Vomiting
  • Weakness
  • Fatigue
  • Dizziness.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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