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Rifampin, pimozide, and ergot medications should never be taken with Lexiva. Drug interactions may occur when these medications are combined that could reduce the effectiveness of the drugs or lead to life-threatening side effects. Some of the other medications that may cause negative Lexiva drug interactions include delavirdine, efavirenz, tricyclic antidepressants, and hormonal contraceptives.

Lexiva Drug Interactions: An Overview

Lexiva® (fosamprenavir calcium) can potentially interact with several other medicines. Some of the medicines that may lead to Lexiva drug interactions include:
  • Arrhythmia medications
  • Bosentan (Tracleer®)
  • Certain antibiotics and antifungal medications, such as:
    • Ketoconazole (Nizoral®)
    • Itraconazole (Sporanox®)
    • Rifabutin (Mycobutin®)
    • Rifampin (Rifadin®)
  • Certain benzodiazepines, such as:


    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergonovine
    • Ergotamine (Cafergot®, Ergomar®)
    • Methylergonovine (Methergine®)
    • Pergolide (Permax®)


Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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