AIDS Home > Lexiva Warnings and Precautions
There are many Lexiva warnings and precautions that you should be aware of before starting treatment. Since Lexiva can cause problems in people with certain medical conditions, tell your healthcare provider if you have hemophilia, diabetes, or liver disease before taking the drug. Lexiva warnings and precautions also apply to anyone who is allergic to amprenavir (a similar medicine) or any components of Lexiva.
You should talk with your healthcare provider prior to taking Lexiva® (fosamprenavir calcium) if you have:
- Liver disease, such as liver failure, cirrhosis, or hepatitis
- High triglycerides or high cholesterol
- Kidney stones
- Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant
You should also be sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
Warnings and precautions to be aware of prior to taking Lexiva include the following:
- The medication can destroy red blood cells (this is known as hemolytic anemia).
- Lexiva frequently causes skin rashes. Most often, these rashes are harmless, although they can be quite dangerous sometimes. Let your healthcare provider know if you develop a rash while taking the drug.
- Lexiva is a sulfonamide ("sulfa") drug. If you have a sulfa allergy, do not take Lexiva without checking with your healthcare provider first.
- The liver helps to remove Lexiva from the blood. Therefore, if you have liver disease, Lexiva may make it worse. Make sure to tell your healthcare provider if you already have liver disease or liver damage prior to taking the drug.
- Lexiva can cause high blood sugar (hyperglycemia). This can cause problems for people with diabetes, or it can even cause diabetes in individuals who are at risk for the condition.
- There have been reports of bleeding possibly due to protease inhibitors (such as Lexiva) in people with hemophilia. Be sure your healthcare provider knows if you have this condition.
- Lexiva can increase triglyceride or cholesterol levels. Your healthcare provider should check your triglyceride and cholesterol levels regularly while you are taking the medication.
- In rare cases, kidney stones have been reported in people taking Lexiva. It is unclear if this was actually related to Lexiva or was merely coincidental. Nevertheless, be sure to talk with your healthcare provider if you have a history of kidney stones.
- The medication can change the distribution of fat on your body. You may gain fat in areas that are not typical for you, such as in the abdomen or at the back of the neck (a "buffalo hump"), and may lose weight in other areas.
- Lexiva is not a cure for HIV or AIDS. If you have HIV or AIDS, you should always use safer sex practices, whether or not you are taking medications.
- As with all HIV medications, it is important that you take Lexiva exactly as prescribed. Missing doses may increase the chance of the virus becoming resistant to HIV medications.
- Lexiva can interact with a number of different medications (see Lexiva Drug Interactions).
- Lexiva is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Lexiva and Pregnancy).
- It is not known if Lexiva passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Lexiva and Breastfeeding). It is important to understand that the HIV virus can be transmitted through breast milk and that breastfeeding is usually not recommended in women with HIV or AIDS.