AIDS Home > Drugs That React With Liposomal Doxorubicin
The following sections explain in detail the potentially negative interactions that can occur when liposomal doxorubicin is combined with any of the drugs listed above.
Cyclophosphamide (Cytoxan, Neosar)
Taking cyclophosphamide with liposomal doxorubicin may increase your risk of side effects. Be sure to talk to your healthcare provider about the risks and benefits of using these medications together.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Combining cyclosporine with liposomal doxorubicin can increase the risk of dangerous side effects, including seizures and problems with bone marrow and blood cells. Talk to your healthcare provider about the risks and benefits of using these medications together.
There have been reports of dangerous side effects when cytarabine was used with liposomal doxorubicin. These included severe inflammation of the colon and bloody stools.
Because chemotherapy (including liposomal doxorubicin) can suppress the immune system, it is generally best to avoid live vaccinations while receiving chemotherapy.
Paclitaxel (Onxol, Taxol)
Taking paclitaxel with liposomal doxorubicin can increase your risk of side effects. Talk to your healthcare provider about the benefits and risks of using these medications together.
Phenobarbital may decrease the level of liposomal doxorubicin in your blood, perhaps making it less effective. Your healthcare provider may need to adjust your liposomal doxorubicin dosage to prevent this drug interaction from occurring.