AIDS Home > What Is Liposomal Doxorubicin Used For?
Liposomal doxorubicin is approved to treat multiple myeloma, AIDS-related Kaposi's sarcoma, and ovarian cancer. However, in some cases, it may also be used "off-label" to treat other types of cancer. At this time, liposomal doxorubicin can only be used in adults -- it has not been studied adequately in people under the age of 18.
An Introduction to the Uses of Liposomal Doxorubicin
Kaposi's sarcoma is a type of cancer that typically affects the skin. Some cases may be mild and may affect the skin only, but other cases can be widespread and may affect other organs as well. In the United States, Kaposi's sarcoma is most commonly seen in people with AIDS, although in other parts of the world, it is seen in people without AIDS.
Kaposi's sarcoma is an AIDS-defining illness. This means that anyone who is HIV-positive who develops Kaposi's sarcoma is automatically given a diagnosis of AIDS, since the cancer is a good indication that the immune system is functioning poorly.
Liposomal doxorubicin is used to treat AIDS-related Kaposi's sarcoma in cases where the cancer has progressed despite prior treatment with combination chemotherapy (chemotherapy involving two or more different medications) or for individuals who are intolerant of such combination chemotherapy options.
Ho Peter. Doxil Breast Cancer NDA: 50-718 (presentation to the Food and Drug Administration Oncologic Drugs Advisory Committee (July 15, 2009). FDA Web site. Available at: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/OncologicDrugsAdvisoryCommittee/UCM176244.pdf. Accessed March 11, 2010.
American Cancer Society (ACS). What Is Kaposi's Sarcoma? (9/17/2009). ACS Web site. Available at: http://www.cancer.org/docroot/cri/content/cri_2_4_1x_what_is_kaposis_sarcoma_21.asp. Accessed March 11, 2010.
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