AIDS Home > Megace Drug Interactions

There are a few drugs that can cause interactions when combined with Megace. Cyclosporine, aminoglutethimide, or certain other medications may alter the amount of Megace in the bloodstream, increasing the risk for side effects or other complications. Your healthcare provider may need to monitor you more closely and adjust your dosage of your medicines to prevent such problems.

An Overview of Interactions With Megace

Megace® (megestrol acetate) may react with a number of other products. Some of the drugs that can interact with Megace include but are not limited to:

Megace Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Megace is combined with any of the drugs listed above.
Aminoglutethimide may decrease blood levels of Megace, possibly making it less effective. Your healthcare provider may need to monitor you more closely if you take these medicines together to make sure Megace is working for you.
Megace may increase the level of cyclosporine in your blood, potentially increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely and give you a lower cyclosporine dosage if you take these medications together.
Megace can increase the level of dofetilide in your blood, which could increase the chance of developing potentially serious side effects. The manufacturer of dofetilide recommends that these medicines not be used together.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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