Available by prescription only, Megace® (megestrol acetate) comes as an oral suspension or a tablet. It is used in the treatment of acquired immunodeficiency syndrome (AIDS), breast cancer, and endometrial cancer (cancer of the lining of the uterus).
Megace oral suspension is usually taken once daily and is approved to treat appetite loss, muscle wasting, and significant weight loss associated with AIDS. The tablets are approved to help relieve symptoms caused by breast cancer or endometrial cancer.
Although most people tolerate this medication well, some people may develop side effects. Common reactions to this medication include diarrhea, a rash, and gas.
(To learn more about this oral medication, click Megace. This resource contains a comprehensive overview of this oral medication, including dosing guidelines, details on how it works, safety precautions, and more.)
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Megestrol Acetate. Drug Facts and Comparisons. Drug Facts and Comparisons 4.0 [online]. 2012. Available from Wolters Kluwer Health, Inc. Accessed April 20, 2012.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed April 19, 2012.
Nilsson S, Nygren KG, Johansson ED. Megestrol acetate concentrations in plasma and milk during administration of an oral contraceptive containing 4 mg megestrol acetate to nursing women. Contraception 1977; 16 (6): 615-624.
National Library of Medicine (US). Hazardous Substances Data Bank (HSDB). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB. Accessed April 20, 2012.
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