AIDS Home > Prezista Side Effects

Unusual or unexplained bleeding, changes in body fat distribution, and high blood sugar are some of the potentially serious side effects that may occur with Prezista. Side effects of the drug are usually minor, however, and don't require medical attention in most cases. Some of the more common side effects of Prezista include high triglycerides, headache, diarrhea, and high cholesterol.

Prezista Side Effects: An Introduction

As with any medicine, side effects are possible with Prezista™ (darunavir ethanolate); however, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Prezista. Your healthcare provider can discuss a more complete list of Prezista side effects with you.)

Common Prezista Side Effects

Clinical studies have not evaluated Prezista alone for the treatment of HIV, since it is meant to be used along with other HIV medications. In fact, the available information on side effects involves studies that used Prezista plus one or two other HIV medications. Therefore, it is difficult to determine whether these side effects are caused by Prezista or the other HIV medications.
Based on these studies, the most common side effects of Prezista (plus one or two other HIV medications) included:
  • High triglycerides -- in up to 25.4 percent of people
  • Diarrhea -- up to 19 percent
  • Vomiting -- up to 14 percent
  • Abdominal pain (stomach pain) -- up to 10 percent
  • Rash -- up to 10 percent
  • Headaches -- up to 9 percent
  • High cholesterol -- up to 9.2 percent
  • Nausea -- up to 4 percent
  • Fatigue -- up to 3 percent
  • Constipation -- up to 2.3 percent.


Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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