Megace and Depression

If you develop any changes in mood, such as depression, while taking Megace® (megestrol acetate), contact your healthcare provider for immediate medical treatment. Clinical trials showed that depression was a common side effect of this medicine, occurring in 2 percent to 5 percent of people.
In most cases, however, side effects tend to be mild and easy to treat. If you are taking Megace and experience anything that "just does not seem right," contact your healthcare provider right away.
(Click Megace Side Effects to learn more about how this drug may cause depression or other side effects. This article lists other possible problems that may occur with Megace and explains when to seek medical attention.)
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