Retrovir Drug Interactions

When medications such as fluconazole, methadone, or rifampin are taken with Retrovir, drug interactions may occur. While some medicines may increase the level of Retrovir in your blood and cause potentially serious side effects, others may decrease Retrovir levels and possibly reduce the effectiveness of the drug. Other medications that can cause Retrovir drug interactions include ritonavir, nelfinavir, probenecid, and ganciclovir.

 

Retrovir Drug Interactions: An Overview

Retrovir® (zidovudine) can potentially interact with several other medicines. Some of the medicines that may lead to Retrovir drug interactions include:
 
  • Atovaquone (Mepron®)
 
 
  • Fluconazole (Diflucan®)
 
  • Ganciclovir (Cytovene®)
 
  • Interferon medications, such as:
o Interferon alfa-2a (Roferon®-A)
o Interferon alfa-2b (Intron® A)
o Interferon alfa-2b and ribavirin (Rebetron®)
o Interferon alfa-n3 (Alferon® N)
o Interferon alfacon-1 (Infergen®)
o Interferon gamma-1b (Actimmune®)
o Peginterferon alfa-2a (Pegasys®)
o Peginterferon alfa-2b (PEG-Intron®)
  • Methadone (Dolophine®, Methadose®)
 
 
  • Probenecid (Benuryl®)
 
  • Ribavirin (Copegus®, Rebetol®, Ribasphere®, Virazole®)
 
  • Rifampin (Ridadin®)
 
  • Rifapentine (Priftin®)
 
 
 
  • Valganciclovir (Valcyte™)
 
 
(Retrovir Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;