Selenium Drug Interactions

When certain medications, such as aspirin or statin cholesterol medications, are taken with selenium, drug interactions may occur. Some of these interactions could reduce the effectiveness of the medicines or increase your risk for developing side effects. To avoid these complications, talk to your healthcare provider about potential selenium drug interactions that may apply to you.

• Medications that "thin" the blood (such as anticoagulant and antiplatelet drugs), such as:
   
  • Antithrombin (ATryn^®, Thrombate III^®)
  • Apixaban (Eliquis^®)
  • Argatroban
  • Aspirin (Bayer^® and others)
  • Bivalirudin (Angiomax^®)
  • Cilostazol (Pletal^®)
  • Clopidogrel (Plavix^®)
  • Dabigatran etexilate mesylate (Pradaxa^®)
  • Dipyridamole (Persantine^®)
  • Drotrecogin alfa (Xigris^®)
  • Eptifibatide (Integrilin^®)
  • Fondaparinux (Arixtra^®)
  • Heparin or heparin-like products, including dalteparin (Fragmin^®), enoxaparin (Lovenox^®), or tinzaparin (Innohep^®)
  • Lepirudin (Refludan^®)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

• • • Celecoxib (Celebrex^®)
    • Diclofenac (Cambia™, Cataflam^®, Flector^®, Solaraze^® Gel, Voltaren^®, Voltaren^® Gel, Voltaren^®-XR, Voltaren Ophthalmic^®, Zipsor™)
    • Ibuprofen (Motrin^®, Advil^®, Nuprin^®)
    • Indomethacin (Indocin^®, Indocin SR^®)
    • Ketoprofen (Orudis^®, Actron^®, Oruvail^®)
    • Ketorolac (Toradol^®)
    • Meloxicam (Mobic^®)
    • Naproxen (Naprosyn^®) or naproxen sodium (Aleve^®, Anaprox^®, Naprelan^®)
    • Several others (see List of NSAIDs for a more complete list of these medications)

• • Pentoxifylline (Trental^®)
  • Prasugrel (Effient^®)
  • Rivaroxaban (Xarelto^®) 
  • Thrombolytics, such as:

• • • Alteplase (Activase^®)
    • Reteplase (Retavase^®)
    • Streptokinase (Streptase^®)
    • Tenecteplase (TNKase^®)

• • Ticagrelor (Brilinta^®)
  • Ticlopidine (Ticlid^®)
  • Tirofiban (Aggrastat^®)
  • Warfarin (Coumadin^®, Jantoven^®)

• Barbiturates, such as:

• • Amobarbital (Amytal^®)
  • Butalbital (Fioricet^®, Fiorinal^®)
  • Pentobarbital (Nembutal^®)
  • Phenobarbital (Luminal^®)
  • Primidone (Mysoline^®)
  • Secobarbital (Seconal^®)

• Niacin (nicotinic acid, Niacor^®, Nicolar^®, Niaspan^®)
• Statin cholesterol medications, such as:

• • Atorvastatin (Lipitor^®) or combination medications that contain atorvastatin (Caduet^®, Liptruzet™)
  • Fluvastatin (Lescol^®, Lescol^® XL)
  • Lovastatin (Altoprev^®, Mevacor^®) or combination medications that contain lovastatin (Advicor^®)
  • Pitavastatin (Livalo^®)
  • Pravastatin (Pravachol^®)
  • Rosuvastatin (Crestor^®)
  • Simvastatin (Zocor^®) or combination medications that contain simvastatin (Juvisync^®, Simcor^®, Vytorin^®).