Sustiva Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when
Sustiva is combined with any of the drugs listed above.
Bepridil
Bepridil and Sustiva should not be taken together due to the risk of serious or life-threatening reactions, such as an irregular heart rhythm (arrhythmia).
Certain Antibiotics or Antifungals
Combining Sustiva with certain antibiotics or antifungals may increase the risk of
Sustiva side effects (due to increased blood levels of Sustiva) or decrease the level of the antibiotic or antifungal in the blood, thereby making it less effective. If you take Sustiva and one of these antibiotics or antifungal medications, your healthcare provider may need to adjust the dose of both medications.
Certain Benzodiazepines
Sustiva can increase the level of certain benzodiazepine medications in the blood, increasing the risk of side effects. With two of these medications (
midazolam and
triazolam), this interaction is so severe that they should never be taken with Sustiva.
Certain Seizure Medications
Taking Sustiva with certain
seizure medications can decrease the level of both Sustiva and the
seizure medication in your blood, making them less effective. Your healthcare provider may need to adjust your dose of these medications to prevent this interaction from occurring.
Diltiazem
Sustiva can decrease the level of
diltiazem in your blood, perhaps making it less effective. Your healthcare provider may need to increase your
diltiazem dosage to prevent this.
Ergot Medications
Sustiva and ergot medications should not be taken together due to the risk of life-threatening reactions.
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