Ethinyl Estradiol
Sustiva can increase the level of ethinyl estradiol in your blood, perhaps increasing the risk of side effects or potentially making
birth control pills less effective. Women taking Sustiva should use a barrier contraceptive method (such as condoms) in addition to birth control pills.
Methadone
Sustiva can decrease the level of methadone in your blood, perhaps making it less effective. Your healthcare provider may need to increase your methadone dosage to prevent this drug interaction from occurring.
Pimozide
Pimozide and Sustiva should not be taken together due to the risk of serious or life-threatening reactions, such as an irregular heart rhythm (arrhythmia).
Protease Inhibitors
Sustiva may interact with protease inhibitors, either increasing or decreasing the level of the protease inhibitor in your blood, depending on the particular medication. Your healthcare provider may need to adjust the dose of your protease inhibitor to prevent this.
Sertraline
Sustiva can decrease the level of
sertraline in your blood, perhaps making it less effective. Your healthcare provider may need to increase your sertraline dosage to prevent this interaction from occurring.
Some Statin Medications
Sustiva can decrease the level of certain statin medications in your blood, perhaps making them less effective. Your healthcare provider may need to increase the dose of your statin medication to prevent this.
St. John's Wort
Because
St. John's wort can greatly reduce the level of Sustiva in your blood, these medications should never be taken together.
Warfarin
Sustiva can interact unpredictably with warfarin. Your healthcare provider may need to monitor you more closely if you are taking both warfarin and Sustiva.