Will Trizivir Cause Fetal Harm?

Zidovudine and Pregnancy
In one study, when zidovudine was given to pregnant rats, it increased the risk of miscarriages but did not seem to increase the risk of birth defects. However, another study suggested that very high doses of zidovudine may cause birth defects in rats. In general, animal studies show that zidovudine is probably safe for use in pregnancy, although there is some evidence that it may affect fertility and very early pregnancy development.
Zidovudine has also been studied in pregnant women. In fact, it is approved to be used during pregnancy to help prevent the transmission of the HIV virus to the baby. In one study, zidovudine reduced the risk of HIV infection in the newborns by up to 86.7 percent. These studies in pregnant women generally showed that zidovudine did not increase the risk of birth defects or other problems.
Lamivudine and Pregnancy
In studies, giving lamivudine to pregnant rabbits appeared to increase the risk of early miscarriages, although this was not seen in studies involving rats. In either rats or rabbits, lamivudine did not seem to increase the risk of birth defects. In general, case reports of lamivudine use in pregnant women suggest that it is probably safe for use in pregnancy.

Trizivir and Pregnancy: Final Thoughts

If you are pregnant, it is always a good idea to ask your healthcare provider before taking any medication. You and your healthcare provider can consider the possible risks and benefits of using Trizivir in your particular situation, as well as any other treatment alternatives. Women with HIV need special prenatal care, both for themselves and to prevent the transmission of HIV to their babies.
Pregnancy and Pain

Trizivir Drug Information

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