Drug Combinations With Viracept to Avoid

Proton Pump Inhibitors (PPIs)
Omeprazole can decrease the level of Viracept in your blood and should not be combined with Viracept. It is not known if this interaction applies to other proton pump inhibitors.
 
Seizure Medications
Some seizure medications can decrease the level of Viracept in your blood, perhaps making it less effective. Check with your healthcare provider before taking Viracept with a seizure medication. Also, Viracept can decrease the level of phenytoin (Dilantin®, Phenytek®) in your blood. Your healthcare provider may need to increase your phenytoin dosage.
 
Some Statin Medications
Viracept should never be combined with lovastatin or simvastatin, due to the risk of dangerous side effects. Since Viracept may increase the level of atorvastatin or rosuvastatin in your blood, your healthcare provider may recommend a lower dosage of these medications or may recommend a different statin that does not interact with Viracept.
 
St. John's Wort
Because St. John's wort can greatly reduce the level of Viracept in your blood, these medications should never be taken together.
 
Trazodone (Desyrel) or Trazodone ER (Oleptro)
Viracept can increase the level of trazodone in your blood. Check with your healthcare provider before taking trazodone with Viracept.
 
Warfarin (Coumadin, Jantoven)
Viracept can increase the level of warfarin in your blood, which may lead to an increased risk of bleeding or other serious side effects. When taking Viracept and warfarin together, your healthcare provider may decide to monitor your warfarin INR (international normalized ratio) more closely, especially when you are starting or stopping Viracept therapy. Your healthcare provider may decide to adjust your warfarin dosage accordingly.
  

Viracept Drug Information

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